Dr. Joanna Sentissi did her undergraduate work at the University of California before going on to earn her MD at the Université Paul Sabatier in Toulouse, France. She completed her internship at Waterbury Hospital in Connecticut, followed by her residency in general surgery as well as vascular research at Tufts New England Medical Center in Boston. After receiving her certification in general surgery with the American Board of Surgery and her licensure in the State of Massachusetts, she continued her training at the Boston Veterans Administration Hospital where she completed a fellowship in vascular surgery. In 1991, she successfully passed the certifying examinations for the American Board of Vascular Surgery. She joined Newton-Wellesley Surgeons in 1993. She is a board certified and actively practicing general and vascular surgeon.

Throughout the years, she has served on numerous committees at Newton-Wellesley Hospital. Currently, she is a member of the peer review committee that monitors quality and outcomes for the surgical service. She is also a Clinical Associate Professor of Surgery at Tufts University School of Medicine.

Her clinical interests and expertise center around minimally invasive vascular surgery, including the endovenous ablation procedure, ambulatory phlebectomy, and sclerotherapy. As of October 2015, she has performed over 2000 of these endovascular venous ablation procedures.